Stem Cells (SCs) are contemplated for a substantial length of your time and big propels are created with reference to stem cell capacities and potential applications in numerous natural and bio-medical areas, for example, organ physiology, tumor pathology, maturing, and regenerative medicine. The idea of a particular micro-environment or "niche" that is required for Stem cells to work developed over three decades back. A few thoughts are advanced to clarify stem cell lineage and fate determination. Current investigate is targeted around the microenvironment or "niche" of stem cells. A stem cell niche is a region of a tissue that provides an optimum micro-environment, in which stem cells are present in an unspecialized and self-renewable state. Cells gift within the stem cell niche moves with the stem cells to take care of them or encourage their differentiation.